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The MPN News feed provides frequent updates on the latest happenings in the MPN World. Fresh content, with brief summary is automatically updated frequently from reliable sources. Just click on the red hyperlink to pull up the complete news item.

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Therapeutic Phlebotomy, Hydroxyurea Improve Overall Survival in Geriatric Polycythemia Vera
from mpn_admin

Treatments with therapeutic phlebotomy and hydroxyurea (HU) are associated with improved overall survival (OS) and decreased risk of thrombosis in older patients with polycythemia vera (PV), according to a recent retrospective cohort study published in Blood Advances.1 PV, a myeloproliferative neoplasm with a median age at diagnosis of 65 years, is [...]

Tue, Nov 13, 2018, Continue reading at the source

Jakafi Granted Priority Review for Acute Graft-Versus-Host Disease
from mpn_admin

Incyte announced that the Food and Drug Administration (FDA) has accepted for Priority Review the supplemental New Drug Application (sNDA) for Jakafi (ruxolitinib) for the treatment of patients with acute graft-versus-host-disease (GVHD) who have had inadequate response to corticosteroids. The sNDA included data from the REACH1 study (N=71) which evaluated ruxolitinib [...]

Wed, Oct 31, 2018, Continue reading at the source

Rare type 1-like and type 2-like calreticulin mutants induce similar MPNS as prevalent type 1 and 2 mutants in mice
from mpn_admin

Frameshift mutations in the calreticulin (CALR) gene are present in 30% of essential thrombocythemia and myelofibrosis patients. The two most frequent mutations are CALR del52 (type 1, approximately 60%) and CALR ins5 (type 2, around 30%), but many other rarer mutations exist accounting each for less than 2% of all [...]

Mon, Oct 22, 2018, Continue reading at the source

MPNs Fall Into Genetic Subgroups With Distinct Clinical Phenotypes
from mpn_admin

NEW YORK (GenomeWeb) – Researchers have uncovered distinct genetic subtypes of myeloproliferative neoplasms, which, in combination with other clinical data, could help guide treatment approaches. Myeloproliferative neoplasms are a group of chronic blood cancers associated with a risk of bleeding and blood clots, but they can also progress to more advanced [...]

Thu, Oct 18, 2018, Continue reading at the source

PharmaEssentia’s testing partner obtains EU certificate
from mpn_admin

PharmaEssentia Corp (藥華醫藥) yesterday announced that its contract testing partner, the Agricultural Technology Research Institute, has obtained the required certifications from the EU as the company prepares to commercialize its new polycythemia drug there. The institute last week received Good Manufacturing Practice (GMP) certification from the European Medicines Agency after working [...]

Thu, Oct 18, 2018, Continue reading at the source

MPNRF blood cancer researcher Robert Kralovics talks about momentous dis...
from Michelle

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Thu, Jan 30, 2014, Continue reading at the source

Gearing up for new round of MF Challenge grants
from Michelle

The applications for the second found of MF Challenge funding will be reviewed on Friday, May 31st in Chicago. In addition to members of the Foundation's Scientific Advisory Board, thought leaders from fibrosis will be joining the review panel as the proposals are judged. In addition to scientific merit, the [...]

Sun, May 26, 2013, Continue reading at the source