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Treatments with therapeutic phlebotomy and hydroxyurea (HU) are associated with improved overall survival (OS) and decreased risk of thrombosis in older patients with polycythemia vera (PV), according to a recent retrospective cohort study published in Blood Advances.1 PV, a myeloproliferative neoplasm with a median age at diagnosis of 65 years, is [...]
Tue, Nov 13, 2018, Continue reading at the source
Incyte announced that the Food and Drug Administration (FDA) has accepted for Priority Review the supplemental New Drug Application (sNDA) for Jakafi (ruxolitinib) for the treatment of patients with acute graft-versus-host-disease (GVHD) who have had inadequate response to corticosteroids. The sNDA included data from the REACH1 study (N=71) which evaluated ruxolitinib [...]
Wed, Oct 31, 2018, Continue reading at the source
Frameshift mutations in the calreticulin (CALR) gene are present in 30% of essential thrombocythemia and myelofibrosis patients. The two most frequent mutations are CALR del52 (type 1, approximately 60%) and CALR ins5 (type 2, around 30%), but many other rarer mutations exist accounting each for less than 2% of all [...]
Mon, Oct 22, 2018, Continue reading at the source
NEW YORK (GenomeWeb) – Researchers have uncovered distinct genetic subtypes of myeloproliferative neoplasms, which, in combination with other clinical data, could help guide treatment approaches. Myeloproliferative neoplasms are a group of chronic blood cancers associated with a risk of bleeding and blood clots, but they can also progress to more advanced [...]
Thu, Oct 18, 2018, Continue reading at the source
PharmaEssentia Corp (藥華醫藥) yesterday announced that its contract testing partner, the Agricultural Technology Research Institute, has obtained the required certifications from the EU as the company prepares to commercialize its new polycythemia drug there. The institute last week received Good Manufacturing Practice (GMP) certification from the European Medicines Agency after working [...]
Thu, Oct 18, 2018, Continue reading at the source
The applications for the second found of MF Challenge funding will be reviewed on Friday, May 31st in Chicago. In addition to members of the Foundation's Scientific Advisory Board, thought leaders from fibrosis will be joining the review panel as the proposals are judged. In addition to scientific merit, the [...]
Sun, May 26, 2013, Continue reading at the source

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