Introduction: The Coronavirus disease 2019 (COVID-19) pandemic and the resulting social distancing, determined a reduction in access to care and limitations of individual freedom, with a consequent strong impact on quality of life (QoL), anxiety levels and medical management of onco-hematological people. In particular, in the case of patients with chronic myeloproliferative neoplasm (MPN), concern […]
Michael’s MPN Story
by Michael Movsky My MPN journey began at the hematologist’s office on a pleasant March day in 2018, when she confirmed a diagnosis of Essential Thrombocytosis (ET) through various factors, including the detection of the JAK 2 mutation…at which point I was handed an informational booklet on the topic from the Leukemia and Lymphoma Society. […]
Inflammatory Microenvironment & Specific T-Cells in MPNs
Abstract The Philadelphia-negative myeloproliferative neoplasms (MPNs) are malignancies of the hematopoietic stem cell (HSC) arising as a consequence of clonal proliferation driven by somatically acquired driver mutations in discrete genes (JAK2, CALR, MPL). In recent years, along with the advances in molecular characterization, the role of immune dysregulation has been achieving increasing relevance in the […]
Covid-19 Vaccines FAQs for Patients and Caregivers
The Leukemia & Lymphoma Society (LLS) hears from blood cancer patients and caregivers each day about the profound effects of the pandemic on their cancer care and daily lives. While it’s been an incredibly trying time, there are bright spots ahead as we all celebrate FDA authorization of two COVID-19 vaccines and look toward more safe, effective vaccines on […]
Precision Medicine and Gene Mutations in MPNs
by David Wallace What does precision medicine look like in MPNs? Can it be used to diagnose, prognosticate and treat patients? Discover information on driver mutations, symptom burden scoring and how it is used in some clinical visits. Learn more as Dr. Naveen Pemmaraju, Associate Professor, Department of Leukemia, Division of Cancer Medicine, The University […]
New MPN Drug Treatments in Development
by David Wallace What are some of the latest combination drug treatments in development for MPN? Find out the latest on combination add-on strategies to JAK inhibitors and other new agents. Two combination therapies for Myelofibrosis look promising as they move into phase 3 clinical trials. They include adding CPI-0610 (a bromodomain, BET, inhibitor) and […]
Clinical Trial Update on Emerging MPN Treatments
by David Wallace Find out the latest news on Ropeginterferon and PTG-300 for treating polycythemia vera, as well as the most promising new treatments for myelofibrosis. What’s the clinical significance of the Allele Burden (AB)? Are there common elements between COVID-19 and MPN…should you get the vaccine? Learn more as Dr. Srdan Verstovsek, Professor, Department of […]
Is the Flu Vaccine effective for MPN patients?
The seasonal influenza A vaccine is recommended for patients with myeloproliferative neoplasms (MPNs). We hypothesised that immune deregulation associated with MPNs may affect the immune response gained following vaccinations when compared to healthy controls. Using deep immunophenotyping with high‐dimensional single‐cell analysis and mass cytometry we could demonstrate an altered immune response in MPN patients following […]
Common MPN Symptom, Living with PV Fatigue
by David Wallace PV Reality – I’m feeling extreme fatigue! Living with polycythemia vera can be like riding a roller coaster. Good days and bad days….never knowing when the “free safety will burst through the offensive line,” rushing in for a QB blitz and the resulting body slam to the ground! I tell myself it’s […]
Actor Jeff Bridges reveals Lymphoma blood cancer
by David Wallace I’m personally shocked and saddened to learn Jeff Bridges, the beloved Oscar winning celebrity and one of my favorite actors has the blood cancer, lymphoma. Our positive healing vibes join millions of fans and fellow lymphoma survivors showing their support for the famous actor…”dude, you got this.” He states “I feel fortunate […]
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