by David Wallace Understanding Thrombosis in MPN Patients Myeloproliferative neoplasms (MPNs) are a group of chronic blood cancers that affect the normal functioning of blood cells. People living with MPNs, such as polycythemia vera (PV), essential thrombocythemia (ET), and myelofibrosis (MF), have an increased risk of developing blood clots, or thrombosis. Thrombosis can lead to […]
Dr. Srdan Verstovsek Joins Kartos Therapeutics as CMO
World-Renowned Physician-Scientist and Global Expert in Myeloproliferative Neoplasms Will Be Instrumental in Advancing the Development of Navtemadlin and Other Innovative Therapies to Improve the Lives of Cancer Patients REDWOOD CITY, Calif., March 02, 2023–(BUSINESS WIRE)–Kartos Therapeutics, Inc. (“Kartos” or the “Company”), a clinical stage biopharmaceutical company dedicated to the development of novel, targeted therapeutics that […]
Modified CALR Mutation helps Identify New Drug Targets for MPN Cancer
Summary The research article discusses myeloproliferative neoplasms (MPN), a type of cancer that affects the blood and bone marrow. It focuses on the Calreticulin (CALR) mutation found in 20% to 25% of MPN patients (with ET and MF) and, which is a potential target for new drug therapies. The authors describe a novel approach using […]
Blood Cancer Discovery: Scientists Create Human Bone Marrow Organoids to Improve Anti-Cancer Treatments
Summary This blood cancer discovery highlights a new approach for investigating blood cancers and bone marrow disorders. MPNs or myeloproliferative neoplasms are blood cancers in which the bone marrow makes too many red blood cells, platelets or white blood cells. Currently, there are limited models available to understand the development and response to treatments of […]
How important is fibrosis in myelofibrosis?
by David Wallace What is fibrosis in myelofibrosis? Myelofibrosis is characterized by an accumulation of fibrous tissue (fibrosis) or scar tissue in the bone marrow. As fibrosis increases, it impairs the bone marrow’s ability to produce healthy blood cells. This can cause numerous symptoms, including anemia, fatigue, weakness and an increased risk of bleeding and […]
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