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Can a drug used to treat arthritis also be a way to treat polycythemia vera (PV), and save patients with the blood cancer money? Researchers at the University of Sheffield in England believe that the chemotherapy agent and immune system suppressant, methotrexate (MTX), would benefit tens of thousands of people affected [...]
Wed, Aug 16, 2017, Continue reading at the source
Atlanta MPN Patient Education Program Thank you for registering for the Women & MPN Patient/Caregiver Education Program on October 26, 2017 in Atlanta, GA. We look forward to seeing you. To complete the registration you can use the link below to pay the registration fee. Follow the brief [...]
Tue, Aug 15, 2017, Continue reading at the source
Mediation Flyer During 2015 and 2016, Arizona State University, in partnership with the Mayo Clinic and Udaya Entertainment, successfully conducted two 12-week, home-based, online-streamed yoga interventions in MPN patients. Through these studies, we demonstrated both the feasibility of online yoga in MPN patients as well as the ability for yoga to [...]
Fri, Aug 11, 2017, Continue reading at the source
SEATTLE, Aug. 1, 2017 /PRNewswire/ — CTI BioPharma Corp. (NASDAQ and MTA: CTIC) today announced that the first patient has been enrolled in PAC203, a Phase 2 clinical trial of pacritinib in patients with primary myelofibrosis who have failed prior ruxolitinib therapy. PAC203 is designed to evaluate the dose response [...]
Wed, Aug 02, 2017, Continue reading at the source
Should you get a genetic test? Myeloproliferative neoplasm (MPN) experts, Dr. Alison Moliterno and Dr. Stephen Oh, help patients understand the driver mutations associated with MPNs such as JAK2V617F, calreticulin (CALR), MPL and others. The experts explain why you should know your genetic mutations and how this knowledge can impact [...]
Wed, Aug 02, 2017, Continue reading at the source
Pegasys Jakafi combo for MPNs
This abstract is provided by Mads Emil Bjorn & Hans Carl Hasselbalch – Department of Hematology, Region Zealand, Roskilde, Denmark Abstract Introduction: The therapeutic landscape of the Philadelphia-negative myeloproliferative neoplasms (MPNs) is markedly changing consequent to the development of JAK-inhibitors and the use of ruxolitinib (RUX) in patients with myelofibrosis (MF) and patients [...]
Thu, Jun 29, 2017, Continue reading at the source
UT (University of Texas) San Antonio makes Dr. Ruben Mesa head of their Cancer Center Dr Ruben Mesa, one of the leading MPN Specialist in the world is accepting the role of the head of UT at San Antonio Cancer Center, where he will remain focused on MPN's. “Dr. Mesa's [...]
Thu, Jun 15, 2017, Continue reading at the source
Immunofluorescence of single human cell stained grown in tissue culture, stained with multiple antibodies and visualized via confocal microscopy
Abstract Myeloproliferative neoplasm cells recruit Gli1 positive mesenchymal stromal cells to transdifferentiate into fibrosis-causing myofibroblasts, a process that can be inhibited by a Gli inhibitor. Bone marrow fibrosis (BMF), characterized by deposition of reticulin and collagen fibers in the marrow, is a hallmark of primary myelofibrosis (PMF) and other myeloproliferative neoplasms (MPNs). [...]
Mon, Jun 05, 2017, Continue reading at the source
Understanding Polycythemia Vera (PV), A Rare Blood Cancer Behind the Mystery, Polycythemia Vera Every year, millions of patients, families and caregivers are impacted by cancer in the United States. Some cancers are well-known, but others are quite rare. Polycythemia Vera (PV) is part of a group of rare blood cancers called [...]
Fri, Apr 28, 2017, Continue reading at the source
Annual Hematology Meeting Updates: CML and MPN
A Solid Summary on the Latest MPN Research in 2017 Drs. Joseph R. Mikhael and Ruben A. Mesa analyze and discuss pertinent clinical studies and late breaking updates pertaining to the care of patients with chronic myelogenous leukemia (CML) and myeloproliferative neoplasms (MPN) in this Best of the Day discussion from [...]
Sun, Jan 29, 2017, Continue reading at the source
For anyone who lives a fast-paced life, it is easy to sometimes forget our need to take care of ourselves and to listen to our bodies. It is easy to get distracted from the importance of a healthy lifestyle when it seems there is so much to be done. But it [...]
Tue, Mar 15, 2016, Continue reading at the source
February 29th is Rare Disease Day: 4 Reasons You Should Care Even though MPN patients who have a rare disease many may have never heard of "Rare Disease Day" and know next to nothing about the impact rare disorders have on society. Rare diseases play a larger role in public [...]
Mon, Feb 29, 2016, Continue reading at the source
It's World Cancer Day There has been, from time to time, a question about whether myeloproliferative neoplasms are cancers. Let's be clear, they are. But don't take our word for it. Cancer Support Community defines Myeloproliferative Neoplasms (MPNs) as types of blood cancers that overproduce blood cells in the bone [...]
Mon, Feb 01, 2016, Continue reading at the source
For the past several months we've kept you informed and taking action on Medicare's pending decision of whether to provide coverage for people with myelofibrosis seeking a stem cell transplant. Currently there is no official ruling from Medicare on whether this treatment is covered, leaving many patients to risk paying [...]
Tue, Jan 12, 2016, Continue reading at the source
Each year for the past three years, Cure Magazine and Incyte Corporation have recognized efforts within the MPN community with their MPN Hero award. The two categories are commitment to the community or individual. Past winners have included Ruben Mesa, Zhenya Senyak, Joyce Niblack, Richard Silver, and many more. We [...]
Sun, Dec 27, 2015, Continue reading at the source
According to a paper published in Nature Medicine, the drug MLN8237 (or Alisertib) has reduced tumor cells, blood counts and fibrosis in mouse models of myelofibrosis. Reports John Crispino, PhD, "This new paper shows that Alisertib has an anti-tumor effect in samples of myelofibrosis, similar to what we saw in [...]
Tue, Dec 01, 2015, Continue reading at the source


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