Differential cytokine network profile in Polycythemia Vera and Secondary Polycythemia

Authors: Maira da Costa Cacemiro, Juçara Gastaldi Cominal, Maria Gabriela Berzoti-Coelho, Raquel Tognon, Natalia de Souza Nunes, Belinda Simões, Ítalo Sousa Pereira, Daniela Carlos, Lucia Helena Faccioli, Lorena Lobo de Figueiredo-Pontes, Fabiani Gai Frantz & Fabíola Attié de Castro Scientific Reports volume 10, Article number: 7032 (2020) Abstract Polycythemia vera (PV) is a clonal disorder resulting from neoplastic transformation of hematopoietic stem cells, while secondary polycythemia (SP) is a disease characterized by increased absolute […]

Immunotherapy in Myeloproliferative Diseases

by Lukas M. Braun 1,2 and Robert Zeiser 1,3,4,5,* 1 Department of Medicine I, Medical Center—University of Freiburg, Faculty of Medicine, University of Freiburg, 79106 Freiburg, Germany; lukas.braun@uniklinik-freiburg.de 2 Faculty of Biology, University of Freiburg, 79104 Freiburg, Germany 3 German Cancer Consortium (DKTK) Partner Site Freiburg, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany 4 […]

NAC N-acetylcysteine Supplement may benefit MPN patients

by Deb Wesloh N-acetylcysteine (NAC) supplement has shown to have Antioxidant and Anti-inflammatory Properties Polycythemia vera, essential thrombocythemia and myelofibrosis make up a class of blood cancers called myeloproliferative neoplasms or MPNs.  MPNs are characterized by the over-production of red or white blood cells or platelets in the bone marrow. MPNs increase the risk of […]

Ocular Manifestations in Patients with Philadelphia Negative Myeloproliferative Neoplasms

Abstract: The major complications of Philadelphia‐negative (Ph‐Negative) myeloproliferative neoplasms (MPNs) are thrombosis, haemorrhage and leukemic transformation. As systemic and haematological diseases, MPNs have the potential to affect many tissues and organs. Some complications lead to the diagnosis of MPNs, but other signs and symptoms are often misdiagnosed or neglected as a sign of MPN disease. […]

Nutrition and Diet May Reduce Chronic Inflammation while Improving Symptom Burden in MPN Patients

Part 3 in a New Series:  “Addressing MPN Symptoms”  Check out the entire series (2020 update)  Over the Counter Combo of Zyrtec and Zantac helping PV patients get relief from itching Polycythemia Vera Brain Fog Nutrition and Diet May Reduce Chronic Inflammation while Improving Symptom Burden in MPN patients Chronic Pain in Over 50 percent […]

The Fleischman Lab Continues Investigating the Role of Inflammation in MPN

2015 MPN Research Update by Dr. Angela Fleischman We are continuing to work on the role of inflammation in MPN.  The human immune system turns on the immune response when it recognizes invaders such as bacteria or viruses by producing inflammatory proteins, also called cytokines.  Cytokines are helpful to fight infection but if the immune […]

High levels of Inflammation disrupt normal blood formation potentially leading to leukemia

Indiana University researchers identify events causing bone marrow inflammation leading to blood disorders Like a line of falling dominos, a cascade of molecular events in the bone marrow produces high levels of inflammation that disrupt normal blood formation and lead to potentially deadly disorders including leukemia. “It has been known for years that there are […]

Bone & Joint Pain in MPN Patients Explained

Pearls of wisdom (1995) by the late Dr. Gilbert Dear Members:  For your information re bone and joint pains in MPN.  Several of you have mentioned that you suffer from bone and/or joint pains – sometimes attributed to arthritis.  I have seen a number of patients who have this complaint and it has been related […]

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