Imetelstat Active in Myeloproliferative Disorders

Drug Active in Myeloproliferative Disorders

Essential thrombocythemia, myelofibrosis respond to telomere targeting Treatment with a drug that targets the chromosome-lengthening enzyme telomerase led to hematologic responses in all treated patients with essential thrombocythemia, a preliminary clinical trial showed. In 16 of 18 cases, patients achieved complete hematologic responses with imetelstat. Additionally, seven of eight patients with Janus kinase 2 (JAK2) […]

MPN Clinical Trial updates from Geron and Promedior

Geron announces removal of Full Clinical Hold on Imetelstat The full clinical hold on Geron’s sole pipeline candidate, investigation new drug (IND), Imetelstat, has been lifted by the FDA.  The company does not intend to conduct further studies or develop imetelstat for the treatment of essential thrombocythemia (ET) or polycythemia vera (PV).  The development plan […]

Imetelstat Trials for MF moves forward as FDA removes hold

clinical trial for MPN

Geron Corp announced today that the partial clinical hold on clinical trials of imetelstat in myelofibrosis has been removed by the FDA. The hold for essential thrombocythemia and polycythemia vera remains. Click here for the full story.

Geron’s Clinical Trials of Imetelstat put on Hold

FDA asks Geron to Halt Development of Imetelstat The FDA has placed it’s only pipeline candidate, imetelstat, on full clinical hold. The news sent shares of GERN plunging 61% on March 12, 2014. Geron had submitted an Investigation New Drug (IND) application for imetelstat, but the FDA issued a verbal notice halting the trials. This […]

Reversal Of Bone Marrow Fibrosis in Myelofibrosis

Imetelstat abstract from ASH

Imetelstat, a Telomerase Inhibitor, Induces Morphologic and Molecular Remissions In Myelofibrosis Geron is studying Imetelstat as a treatment for Myelofibrosis, a disease in which abnormal blood cells build up in the bone marrow, forming thick scar tissues that slows the production of healthy blood cells.  Other MF drugs treat the symptoms of the disease (Jakafi). […]

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