The U.S. Food and Drug Administration (FDA) has granted Fast Track designation to givinostat, an oral histone deacetylase inhibitor (HDACi) developed by Italfarmaco S.p.A., for the treatment of polycythemia vera (PV), a rare hematologic malignancy. This designation aims to expedite the development and review of drugs that address serious conditions with unmet medical needs. PV […]
Gut Microbiome and Polycythemia Vera: What You Should Know
by David Wallace Recent research has uncovered significant differences in the gut microbiota of individuals with polycythemia vera (PV) compared to healthy individuals. Polycythemia vera, an uncommon blood cancer classified as a myeloproliferative neoplasm (MPN), causes abnormal blood cell growth and is characterized by chronic inflammation. The Importance of Gut Health Your gut microbiota, the […]
MPN Symptom Burden: Discrepancy Between Patients & Doctors
Doctors Miss the Mark on MPN Symptoms, New Study Shows by David Wallace We’ve suspected it for years, but now there’s proof: doctors aren’t fully grasping how bad MPN symptoms really are for patients. I just read this eye-opening study from a German research group that tracked almost 4,000 MPN patients, and the disconnect between […]
UVA Researcher Receives $2.4M for MPN Progression Study
by David Wallace The National Institutes of Health (NIH) has awarded a $2.4 million grant to Dr. Golam Mohi, a professor in the Department of Biochemistry and Molecular Genetics at the University of Virginia, to advance understanding of a group of blood cancers known as myeloproliferative neoplasms (MPNs). The research project, titled “Molecular Basis for […]
PV Remission to Recovery: Overcoming Life’s Challenges
by David Wallace A New Year, a New Perspective As 2025 begins, I’ve been reflecting on the unpredictable journey of aging—a path that’s less about smooth sailing and more about navigating challenges. After four years living in remission from polycythemia vera (PV), I’ve come to understand that maintaining good health requires resilience to overcome challenges […]
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