Nutrition and Diet May Reduce Chronic Inflammation while Improving Symptom Burden in MPN Patients

Part 3 in a New Series:  “Addressing MPN Symptoms” 

Check out the entire series (2020 update) 

Nutrition for MPN Patients

We know diet plays a role in inflammation.  Chronic inflammation may be an important driving force for clonal evolution and disease progression in myeloproliferative neoplasms (MPNs), essential thrombocythemia (ET), polycythemia vera (PV), and myelofibrosis (MF).  So with that in mind, eating a healthy, nutritious diet may help improve your overall symptom burden.  Other factors like stress, physical activity, sleep patterns, central adiposity (fancy word for accumulation of fat around the belly) play a role in chronic inflammation.

Dietary Inflammatory Index (DII) is a score used to describe the potential of diet to modulate systemic inflammation in the body.  Dietary factors with Anti-inflammatory score include phytochemicals and micronutrients commonly found in vegetables and fruits, whole grains/fiber, certain spices and seasonings (garlic, turmeric, ginger, turmeric, chili peppers and more).

physical health for MPN patients, mpn diet

CLICK HERE for article – Curcumin induces apoptosis in JAK2-mutated cells

Cytokines and Cellular Mediators involved in the inflammatory process include:

  • IL-6 (interleukin-6)
  • NF-kappa B (nuclear factor kappa-light-chain, enhancer of activated B cells)
  • COX2 (cyclooxygenase – 2)
  • TNF-a (cytokine in macrophages)
  • IFN-y (cytokine in T cells and NK cells
  • IL-1 (chemokine in macrophages)
  • Eicosanoids including leukotrienes and prostaglandins

The key point is certain foods support healthy regulation of inflammation – Low DII (Anti-inflammatory Foods).  Some of the above mediators are anti-inflammatory, while others are proinflammatory.

Read the Presentation Below, by Carolyn Katzin, for the complete story:

If you would like to download the PDF click here  



Free Dietitian Consultation:

The Leukemia & Lymphoma Society (LLS) provides PearlPoint Nutrition Services to patients and caregivers of all cancer types (naturally MPNs are included).  The program provides free nutrition education and consultation.

About the Author:

Carolyn Katzin is a Certified Nutrition Specialist with thirty years of experience in clinical nutrition with an emphasis on optimizing well-being.  Her expertise is in oncology, genetics and genomics and immunology.  She recognizes the value of diet and lifestyle in these aspects of health.  She has three books in print, The Good Eating Guide & Cookbook, The Cancer Nutrition Center Handbook and the EVERYTHING Cancer Fighting Cookbook.  Ms. Katzin stays current with the emerging field of applied genomics.  In 2017, she received a professional certificate in genetics & genomics from Stanford University (6 courses, two covering cancer specifically).  In addition, she has completed certification courses in nutrigenomics at University of California, Davis and NuGO, the European Nutrigenomics Organisation.  She offers compassionate, helpful and meaningful nutrition counseling for cancer patients and their loved ones at UCLA Simms/Mann Center for Integrative Oncology both in person and online.


About David Wallace

Founder of PV Reporter, a resource for Myeloproliferative Neoplasm (MPN) patients and caregivers. After being diagnosed with Polycythemia Vera (PV) in 2009, I utilized social media to connect with "informed patients" and develop a better understanding of emerging treatment options. My philosophy on patient care is straight forward - "educating the patient is essential, so the patient can guide their physician to meet his or her needs." PV Reporter is a comprehensive resource hub giving visitors vital tools to become "empowered patients."

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