JAK2 p.V617F detection and allele burden measurement in peripheral blood and bone marrow aspirates in patients with myeloproliferative neoplasms

MPN red blood cellsKey points

  • The sensitivity and specificity of detecting the JAK2 p.V617F mutation in peripheral blood are both 100% compared to bone marrow.
  • The JAK2 p.V617F allele burden measured in peripheral blood is equivalent to that in bone marrow aspirate (R2=0.991; P<0.0001).

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