Indiana University researchers identify events causing bone marrow inflammation leading to blood disorders
Like a line of falling dominos, a cascade of molecular events in the bone marrow produces high levels of inflammation that disrupt normal blood formation and lead to potentially deadly disorders including leukemia.
“It has been known for years that there are links between inflammation and cancer, but these studies have been challenged by the lack of genetic models, especially for blood-based malignancies,” said Dr. Carlesso, a member of the hematologic malignancy and stem cell biology program within the Wells Center for Pediatric Research at IU.
The researchers focused on what happens when there are abnormally low levels of a molecule called Notch, which plays an important role in the process of blood cell production. Using a genetically modified mouse, they found that the loss of Notch function in the microenvironment causes a chain of molecular events that result in excess production of inflammatory factors.
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Below is a short video discussing the work of Dr. Carlesso