High levels of Inflammation disrupt normal blood formation potentially leading to leukemia

Indiana University researchers identify events causing bone marrow inflammation leading to blood disorders

Nadia Carlesso MD_opt

Nadia Carlesso MD, PhD

Like a line of falling dominos, a cascade of molecular events in the bone marrow produces high levels of inflammation that disrupt normal blood formation and lead to potentially deadly disorders including leukemia.

“It has been known for years that there are links between inflammation and cancer, but these studies have been challenged by the lack of genetic models, especially for blood-based malignancies,” said Dr. Carlesso, a member of the hematologic malignancy and stem cell biology program within the Wells Center for Pediatric Research at IU.

The researchers focused on what happens when there are abnormally low levels of a molecule called Notch, which plays an important role in the process of blood cell production.  Using a genetically modified mouse, they found that the loss of Notch function in the microenvironment causes a chain of molecular events that result in excess production of inflammatory factors.

The high levels of inflammation in the bone marrow were associated with the development of a myeloproliferative disorder in the mice.  Myeloproliferative diseases in humans can result in several illnesses caused by overproduction of myeloid cells, which are normally are used to fight infections.  These diseases can put patients at risk for heart attack or stroke, and frequently progress into acute leukemia and bone marrow failure, which have fatal outcomes.  Unfortunately, there are no effective therapies for the majority of myeloproliferative diseases.

Click below for the entire article:


Indiana University School of Medicine – Researchers identify events causing bone marrow inflammation leading to blood disorders

Click here to download the pdf

Below is a short video discussing the work of Dr. Carlesso

It should be noted that Nadia Carlesso, MD, Phd is one of the winners of grant funding from the MPN Research Foundation and LLS.


 

About David Wallace

Founder of PV Reporter, a resource for Myeloproliferative Neoplasm (MPN) patients and caregivers. After being diagnosed with Polycythemia Vera (PV) in 2009, I utilized social media to connect with "informed patients" and develop a better understanding of emerging treatment options. My philosophy on patient care is straight forward - "educating the patient is essential, so the patient can guide their physician to meet his or her needs." PV Reporter is a comprehensive resource hub giving visitors vital tools to become "empowered patients."

error: Content is protected !
Malcare WordPress Security